4-Bromo-3,5-difluorobenzoic acid(CAS: 651027-00-8)

4-Bromo-3,5-difluorobenzoic acid is a white crystalline solid with a molecular weight of 255.03 g/mol. It has a pKa of 4.5 and is only slightly soluble in water. The compound is highly reactive due to its functional groups and bromine substituent. It can undergo reactions such as esterification and bromination.

4-Bromo-3,5-difluorobenzoic acid is typically synthesized through a two-step process: first, 3,5-difluorobenzoic acid is brominated, and then the resulting bromide is converted to the carboxylic acid. Common reagents include bromine and a Lewis acid catalyst like aluminum bromide.

4-Bromo-3,5-difluorobenzoic acid is used in various industries, including pharmaceuticals for the synthesis of certain drugs, and in the production of organic semiconductors and sensors. It is also utilized in the preparation of polymers with specific electronic properties.

Proper handling of 4-Bromo-3,5-difluorobenzoic acid requires the use of chemical protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood due to its reactive nature. Spills should be cleaned up with caution, and the Material Safety Data Sheet (MSDS) should be consulted for specific procedures. Ensure proper ventilation and avoid inhalation or contact with skin and eyes.