(2S)-2-Hydroxy-4-methylpentanoic acid(CAS: 13748-90-8)

(2S)-2-Hydroxy-4-methylpentanoic acid is a colorless crystalline solid with a molecular weight of approximately 146.18 g/mol. It has a pKa of 2.7 and is moderately soluble in water. The compound shows limited reactivity under normal conditions but can undergo esterification and amide formation. It is sparingly soluble in common organic solvents like ethanol and acetone.

(2S)-2-Hydroxy-4-methylpentanoic acid can be synthesized from 4-methylpentanoyl chloride and sodium hydroxide in an aqueous medium. The reaction proceeds with high selectivity to the (2S) configuration. The yield is typically around 75-85%, and the product can be isolated by recrystallization from water or methanol.

(2S)-2-Hydroxy-4-methylpentanoic acid finds applications in the pharmaceutical industry as a precursor for certain drug molecules. It is also used in the polymer industry for modifying properties of polymers. Additionally, it has potential uses in the food industry as a flavor enhancer and in the sensor industry for detecting organic compounds.

When handling (2S)-2-Hydroxy-4-methylpentanoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and goggles. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, use absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.