LY294002(CAS: 154447-36-6)

LY294002 is a white to off-white crystalline powder with a molecular weight of approximately 396.27 g/mol. It is sparingly soluble in water but readily soluble in organic solvents like DMSO and ethanol. Chemically, it is known for its high reactivity, particularly in phosphate kinase inhibition studies.

LY294002 is typically synthesized through a multi-step organic reaction involving the condensation of an amide with an aldehyde followed by subsequent functional group manipulations. Common catalysts include Lewis acids, and the reaction is carried out in polar aprotic solvents such as DMF. The overall yield is around 60-70%, with high selectivity for the desired product.

LY294002 is primarily used in the pharmaceutical industry for its role as a selective phosphatidylinositol 3-kinase (PI3K) inhibitor. It is also utilized in academic and industrial research for studying cellular signaling pathways and in the development of potential therapeutics for diseases such as cancer and autoimmune disorders.

When handling LY294002, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be carried out in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate tools and materials, and disposal should follow local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.