5-(Benzyloxy)-2,4-dichloropyrimidine(CAS: 91183-17-4)

5-(Benzyloxy)-2,4-dichloropyrimidine (CAS: 91183-17-4) is a crystalline solid with a molecular weight of approximately 326.03 g/mol. It has a melting point of around 125-128°C. The compound is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. It shows moderate reactivity, particularly towards nucleophiles, and can undergo substitution reactions under appropriate conditions.

5-(Benzyloxy)-2,4-dichloropyrimidine (CAS: 91183-17-4) can be synthesized through a multistep process involving the protection of a chloropyrimidine with a benzyloxy group followed by deprotection. Common synthetic methods include the use of benzyloxycarbonyl (Boc) protection, which is then removed using trifluoroacetic acid (TFA). The overall yield can be around 60-70%, with high regioselectivity and chemoselectivity.

5-(Benzyloxy)-2,4-dichloropyrimidine (CAS: 91183-17-4) is primarily used in the pharmaceutical industry for the synthesis of various drugs. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it can be used in the production of sensors and semiconductors for electronic devices.

When handling 5-(Benzyloxy)-2,4-dichloropyrimidine (CAS: 91183-17-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the safety data sheet (SDS) for detailed handling and storage guidelines.