1-Bromo-2-fluoro-4-(trifluoromethyl)benzene(CAS: 40161-54-4)

1-Bromo-2-fluoro-4-(trifluoromethyl)benzene (CAS: 40161-54-4) is a crystalline solid with a molecular weight of approximately 302.04 g/mol. It has a low water solubility and high solubility in organic solvents like dichloromethane and ethyl acetate. This compound is chemically reactive, particularly towards nucleophiles, and can undergo substitution and elimination reactions.

1-Bromo-2-fluoro-4-(trifluoromethyl)benzene can be synthesized via bromination of 2-fluoro-4-(trifluoromethyl)benzene using N-bromosuccinimide (NBS) in the presence of a radical initiator, such as azobisisobutyronitrile (AIBN). The reaction is typically carried out under UV light or heat to achieve a yield of approximately 70–80%.

1-Bromo-2-fluoro-4-(trifluoromethyl)benzene (CAS: 40161-54-4) is used in the pharmaceutical industry for the synthesis of drug intermediates and in polymer science for the modification of polymers. It also finds applications in the semiconductor industry for the fabrication of electronic materials and in chemical sensors for detection of various substances.

When handling 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene (CAS: 40161-54-4), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be stored in a fume hood and handled in a well-ventilated area. Spills should be cleaned up immediately using appropriate PPE and chemical waste protocols should be followed. Always refer to the safety data sheet (SDS) for detailed handling instructions.