ethyl 2-(ethoxymethylene)-3-oxo-butanoate(CAS: 3788-94-1)

Ethyl 2-(ethoxymethylene)-3-oxo-butanoate is a colorless liquid with a molecular weight of approximately 144.22 g/mol. It has a high solubility in organic solvents such as ethanol and has good reactivity in esterification and amidation reactions. The compound is stable under normal conditions but may undergo hydrolysis in the presence of moisture.

Ethyl 2-(ethoxymethylene)-3-oxo-butanoate is typically synthesized by the reaction of ethyl acetoacetate with ethyl vinyl ether in the presence of a catalytic amount of an acid, such as hydrochloric acid. The reaction yields a high selectivity and good yield, making it a practical and efficient method for producing this compound.

Ethyl 2-(ethoxymethylene)-3-oxo-butanoate is used in the pharmaceutical industry for the synthesis of certain drugs, as well as in the polymer industry for the modification of polymers. It is also employed in the sensor and semiconductor industries for the development of specific chemical sensors and materials.

When handling ethyl 2-(ethoxymethylene)-3-oxo-butanoate, ensure the use of personal protective equipment (PPE) such as gloves and safety goggles. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of spillage, use appropriate spill cleanup methods and refer to the safety data sheet (SDS) for further guidance.