Ganciclovir Mono-O-acetate(CAS: 88110-89-8)

Ganciclovir Mono-O-acetate (CAS: 88110-89-8) is a white or off-white crystalline powder with a molecular weight of approximately 367.4 g/mol. It is moderately soluble in water and ethanol. Chemically, it is stable under normal conditions but can be hydrolyzed in strong acidic or basic conditions. It reacts readily with nucleophiles, making it useful for further chemical modifications.

Ganciclovir Mono-O-acetate (CAS: 88110-89-8) is typically synthesized by acetylation of ganciclovir. The reaction involves treating ganciclovir with acetic anhydride in the presence of a catalytic amount of an acid, such as sulfuric acid or p-toluenesulfonic acid, resulting in a high yield of the mono-O-acetate derivative.

Ganciclovir Mono-O-acetate (CAS: 88110-89-8) is primarily used in the pharmaceutical industry for the synthesis of antiviral drugs. It is also utilized in the research and development of new drugs targeting herpes simplex virus and cytomegalovirus.

When handling Ganciclovir Mono-O-acetate (CAS: 88110-89-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Handle in a well-ventilated area or under a fume hood to minimize exposure. Spills should be cleaned up immediately with appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed spill procedures.