4-Bromo-2-pyridinol(CAS: 36953-37-4)

4-Bromo-2-pyridinol is a white crystalline solid with a molecular weight of approximately 177.03 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound shows moderate reactivity towards nucleophiles and can undergo substitution reactions. It has a melting point of around 135-137°C and a boiling point of about 210-212°C under reduced pressure.

4-Bromo-2-pyridinol is commonly synthesized via the bromination of 2-pyridol followed by hydrolysis of the bromopyridyl derivative. Commonly used brominating agents include phosphorus tribromide or bromine in the presence of appropriate solvents. The reaction is typically carried out under anhydrous conditions to improve yield and purity.

4-Bromo-2-pyridinol is used in various industries, particularly in pharmaceuticals for the synthesis of certain drug intermediates. It also finds applications in the preparation of dyes and pigments, as well as in research for its potential use as a chemosensor and in organic electronics.

Proper protective equipment such as gloves, safety goggles, and a lab coat should be worn when handling 4-Bromo-2-pyridinol. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbent materials, followed by thorough decontamination. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.