4-cyanobenzoyl chloride(CAS: 6068-72-0)

4-Cyanobenzoyl chloride is a white crystalline solid with a high melting point of 95-96°C. Its molecular weight is approximately 223.17 g/mol. It is slightly soluble in water but readily soluble in organic solvents like ethanol and dichloromethane. The compound is highly reactive, especially towards nucleophiles, and undergoes substitution reactions readily.

4-Cyanobenzoyl chloride is typically synthesized by the reaction of 4-cyanobenzoic acid or 4-cyanobenzoyl halide with thionyl chloride. The reaction is carried out in a solvent such as toluene or dichloromethane at room temperature with good yields and high selectivity.

4-Cyanobenzoyl chloride finds applications in pharmaceuticals, where it serves as an intermediate in the synthesis of drugs. It is also used in the production of dyes, pigments, and as a reagent in polymer chemistry and semiconductor materials.

Proper handling of 4-cyanobenzoyl chloride requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled with appropriate absorbents, and the material safety data sheet (MSDS) or safety data sheet (SDS) should be consulted for detailed spill management procedures.