3-Bromo-5-fluoro-2(1H)-pyridinone(CAS: 884494-94-4)

3-Bromo-5-fluoro-2(1H)-pyridinone is a crystalline solid with a molecular weight of approximately 228.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetone. This compound is moderately reactive towards nucleophiles and electrophiles. It exhibits good stability under normal conditions but requires protection from moisture and light to prevent hydrolysis.

3-Bromo-5-fluoro-2(1H)-pyridinone can be synthesized through a bromination reaction of 5-fluoropyridine with N-bromosuccinimide (NBS) in the presence of a suitable initiator like benzoyl peroxide. This process yields the product with good selectivity and a moderate yield of approximately 70-80%. The reaction is conducted under anhydrous conditions to avoid side reactions.

3-Bromo-5-fluoro-2(1H)-pyridinone is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various medicinal compounds and is also used in the development of sensors and materials due to its unique chemical properties. Its applications in polymers and semiconductors are also being explored.

When handling 3-Bromo-5-fluoro-2(1H)-pyridinone, it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a laboratory coat. The compound should be handled in a well-ventilated area or under a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using absorbent materials, and the area should be flushed with water. It is advisable to consult the Safety Data Sheet (SDS) for more detailed information on handling and storage procedures.