Methyl 2-chloroisonicotinate(CAS: 58481-11-1)

Methyl 2-chloroisonicotinate (CAS: 58481-11-1) is a crystalline compound with a molecular weight of approximately 169.62 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. This compound is known for its moderate reactivity, particularly towards nucleophiles. It has a melting point of around 79-81°C and a boiling point of about 215-217°C. It is stable under normal storage conditions but should be handled with care due to its reactive nature.

Methyl 2-chloroisonicotinate (CAS: 58481-11-1) is typically synthesized by the reaction of methyl isonicotinate with hydrochloric acid. The process involves the substitution of the hydroxyl group with a chlorine atom. Commonly, this reaction is carried out in the presence of a mild base like sodium hydroxide to improve selectivity and yield. The overall reaction is highly exothermic, and proper temperature control is essential to achieve the desired product.

Methyl 2-chloroisonicotinate (CAS: 58481-11-1) finds applications in various industries. It is used in the pharmaceutical sector for the synthesis of certain drugs, particularly those involving isonicotinic acid derivatives. In the polymer industry, it serves as a precursor for the production of certain types of polymeric materials. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical properties.

When handling Methyl 2-chloroisonicotinate (CAS: 58481-11-1), it is crucial to follow strict safety protocols. Always wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure to the compound. Spills should be cleaned up promptly using appropriate absorbents, and proper disposal methods should be followed. Always refer to a Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.