Compound Q&A
How is Methyl 2-chloroisonicotinate (CAS: 58481-11-1) typically synthesized?
Answer
Methyl 2-chloroisonicotinate (CAS: 58481-11-1) is typically synthesized by the reaction of methyl isonicotinate with hydrochloric acid. The process involves the substitution of the hydroxyl group with a chlorine atom. Commonly, this reaction is carried out in the presence of a mild base like sodium hydroxide to improve selectivity and yield. The overall reaction is highly exothermic, and proper temperature control is essential to achieve the desired product.
About
CAS No
58481-11-1
English Name
Methyl 2-chloroisonicotinate
Molecular Formula
C7H6ClNO2
Molecular Weight
171.58 g/mol
SMILES
COC(=O)C1=CC(=NC=C1)Cl
InChIKey
KKOUHTMLFUAAGG-UHFFFAOYSA-N
Last Updated: 2025-09-13 09:53
