2,2'-Biquinoline-4,4'-dicarboxylic acid(CAS: 1245-13-2)

2,2'-Biquinoline-4,4'-dicarboxylic acid is a crystalline solid with a molecular weight of approximately 282.11 g/mol. It has a solubility of about 16 g/L in water and is moderately reactive, particularly towards nucleophilic substitution reactions. It is insoluble in common organic solvents like ethanol and acetone.

2,2'-Biquinoline-4,4'-dicarboxylic acid is typically synthesized via the Barton-McCombie deoxygenation of 2,2'-biquinoline, followed by the introduction of carboxylic acid groups. Common catalysts include copper(II) chloride and boron trifluoride etherate, with high selectivity and yields up to 90%.

2,2'-Biquinoline-4,4'-dicarboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, in the polymer industry for the development of novel materials, in the semiconductor industry for the fabrication of organic semiconductors, and in chemical sensing applications for the construction of gas sensors.

When handling 2,2'-Biquinoline-4,4'-dicarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a cool, dry, and well-ventilated area, and handled in a fume hood to minimize exposure. In case of a spill, it should be cleaned up according to the Material Safety Data Sheet (MSDS) guidelines.