4-(4-Pyridinyl)-1-butanol(CAS: 5264-15-3)

4-(4-Pyridinyl)-1-butanol (CAS: 5264-15-3) is a colorless liquid with a molecular weight of approximately 147.16 g/mol. It has a pKa of about 14.2 and exhibits moderate solubility in water (0.5 g/100 mL at 20°C). This compound is poorly soluble in nonpolar solvents. It is moderately reactive towards nucleophiles and can form complexes with various metal ions. The compound is crystalline at lower temperatures and has a melting point of 108-109°C.

4-(4-Pyridinyl)-1-butanol (CAS: 5264-15-3) is typically synthesized via the condensation of 4-pyridinecarboxaldehyde with 1-butanol using a base like potassium hydroxide as a catalyst. The reaction is carried out in a non-aqueous solvent such as acetonitrile at room temperature. The yield is generally around 70-80%, and the reaction is highly selective, making it a reliable method for obtaining the desired product.

4-(4-Pyridinyl)-1-butanol (CAS: 5264-15-3) is primarily used in the pharmaceutical industry for the synthesis of pharmaceutical intermediates and as a chelating agent in metal-based drugs. It also finds applications in the polymer industry as a modifying agent and in the development of sensors and semiconductors for its unique physicochemical properties.

When handling 4-(4-Pyridinyl)-1-butanol (CAS: 5264-15-3), it is important to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of vapors. Spills should be cleaned up immediately using appropriate absorbent materials and following standard safety protocols. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.