4,6-Dichloro-2-(3-pyridinyl)pyrimidine(CAS: 89508-47-4)

4,6-Dichloro-2-(3-pyridinyl)pyrimidine (CAS: 89508-47-4) is a crystalline solid with a molecular weight of approximately 268.04 g/mol. It has a melting point of 183-185°C and is poorly soluble in water but soluble in common organic solvents like methanol and ethanol. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions.

4,6-Dichloro-2-(3-pyridinyl)pyrimidine is typically synthesized through the condensation of 2-aminopyrimidine with 3-chloropyridine in the presence of a base like sodium hydride. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF) under anhydrous conditions. The process yields a highly selective product with good purity and yield.

4,6-Dichloro-2-(3-pyridinyl)pyrimidine (CAS: 89508-47-4) is primarily used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds applications in the development of new materials, particularly in the area of semiconductors and sensors, due to its unique chemical properties.

When handling 4,6-Dichloro-2-(3-pyridinyl)pyrimidine (CAS: 89508-47-4), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize exposure to vapors. Spills should be cleaned up carefully following standard procedures, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.