(S)-(-)-2-Methylbutanol(CAS: 1565-80-6)

(S)-(-)-2-Methylbutanol is a colorless liquid with a slightly acetone-like odor. It has a molecular weight of 98.15 g/mol and a boiling point of 83.7°C. The compound is slightly soluble in water and readily soluble in organic solvents. It shows good reactivity in nucleophilic substitution reactions and exhibits a slight acidity due to the hydroxyl group.

(S)-(-)-2-Methylbutanol can be synthesized via a stereoselective reduction of 2-methylbutan-2-one using a chiral auxiliary. The reaction is performed under mild conditions, yielding a high enantiomeric excess. Another method involves the hydrogenation of racemic 2-methylbutanal, followed by resolution using a chiral stationary phase in HPLC.

(S)-(-)-2-Methylbutanol is widely used in the pharmaceutical industry as a chiral auxiliary for the synthesis of enantiomerically pure compounds. It is also employed in the manufacturing of fragrances and flavorings, as well as in the production of chiral polymers and electronics materials due to its chiral nature.

When handling (S)-(-)-2-Methylbutanol, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to avoid inhalation of vapors. Spills should be cleaned up immediately using absorbent materials and appropriate waste handling procedures. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.