8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one(CAS: 31251-41-9)

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is a white to off-white crystalline solid with a molecular weight of approximately 252.04 g/mol. It has limited water solubility and is soluble in organic solvents like dichloromethane and ethanol. The compound is moderately reactive, especially under basic conditions, and may undergo ring-opening or substitution reactions.

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one can be synthesized through a multi-step process involving acylation, cyclization, and chlorination. Commonly, a pyridine derivative is first acylated, then cyclized to form the core structure, and finally chlorinated to introduce the chlorine substituent. The reaction conditions include the use of acylating agents like acid chlorides and bases such as sodium hydride.

8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one is primarily used in the pharmaceutical industry for the development of medications, particularly in the synthesis of certain bioactive compounds. It may also find applications in the polymer industry for modifying the properties of polymers and in the field of sensors for its chemical reactivity.

When handling 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. The compound should be stored in a well-ventilated area, and fume hoods should be used during handling to avoid inhalation. Spills should be cleaned up immediately with appropriate absorbent materials and proper disposal methods. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.