5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine(CAS: 876343-82-7)

5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine is a crystalline solid with a molecular weight of approximately 260.03 g/mol. It is slightly soluble in water and organic solvents like dimethylformamide (DMF) and acetonitrile. It exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It is stable under normal laboratory conditions but should be stored in airtight containers to prevent moisture absorption.

5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine is commonly synthesized through electrophilic aromatic substitution reactions. A typical method involves the bromination and chlorination of 1H-pyrrolo[2,3-b]pyridine with bromine and chlorine, respectively, in the presence of a catalyst such as iron(III) chloride. The yield and selectivity are controlled by the reaction conditions and the choice of solvents.

5-Bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those targeting specific biological pathways. It is also utilized in the polymer industry for the development of novel materials and in the field of sensors for its capability to act as a receptor or indicator.

When handling 5-bromo-4-chloro-1H-pyrrolo[2,3-b]pyridine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be conducted in a well-ventilated fume hood due to its potential to generate toxic fumes during synthesis or use. In case of a spill, immediately clean up using appropriate absorbent materials and follow safety data sheet (SDS) guidelines for disposal. Storage should be in a secure, airtight container to prevent contamination and degradation.