2,8-Bis(trifluoromethyl)-4-quinolinol(CAS: 35853-41-9)

2,8-Bis(trifluoromethyl)-4-quinolinol is a crystalline compound with a molecular weight of approximately 344.13 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and THF. It is highly reactive towards nucleophiles and electrophiles. Its biodegradation is minimal, and it does not pose a significant environmental risk.

2,8-Bis(trifluoromethyl)-4-quinolinol is generally synthesized via a multistep process, involving the alkylation of 4-quinolinol with trifluoromethyl iodide, followed by deprotonation and quenching with a base. The reaction is typically catalyzed by sodium hydride and proceeds with a yield of around 70-80%.

2,8-Bis(trifluoromethyl)-4-quinolinol finds applications in pharmaceutical industries for its potential as a ligand in metal-based anticancer drugs. It is also utilized in the development of sensors and semiconductors due to its unique electronic properties and fluorescence characteristics.

When handling 2,8-Bis(trifluoromethyl)-4-quinolinol, use appropriate PPE including gloves, safety glasses, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of vapors. Store it in a cool, dark place away from direct sunlight. In case of spill, use appropriate spill cleanup materials and consult the Safety Data Sheet (SDS) for further instructions.