Compound Q&A
How is 2,8-Bis(trifluoromethyl)-4-quinolinol (CAS: 35853-41-9) typically synthesized?
Answer
2,8-Bis(trifluoromethyl)-4-quinolinol is generally synthesized via a multistep process, involving the alkylation of 4-quinolinol with trifluoromethyl iodide, followed by deprotonation and quenching with a base. The reaction is typically catalyzed by sodium hydride and proceeds with a yield of around 70-80%.
About
CAS No
35853-41-9
English Name
2,8-Bis(trifluoromethyl)-4-quinolinol
Molecular Formula
C11H5F6NO
Molecular Weight
281.16 g/mol
SMILES
OC1=CC(C(F)(F)F)=NC2=C(C(F)(F)F)C=CC=C12
InChIKey
JIWHKBAFGFPZKM-UHFFFAOYSA-N
Last Updated: 2025-09-16 13:49
