Tert-butyl 4-amino-1H-indazole-1-carboxylate(CAS: 8016-13-5)

Tert-butyl 4-amino-1H-indazole-1-carboxylate (CAS: 8016-13-5) is a white to off-white crystalline solid with a molecular weight of approximately 278.4 g/mol. It is slightly soluble in water but soluble in organic solvents like dichloromethane and ethanol. It exhibits good stability under normal conditions but is reactive towards bases and reducing agents.

Tert-butyl 4-amino-1H-indazole-1-carboxylate can be synthesized via the coupling of tert-butyl 4-bromomethyl-1H-indazole-1-carboxylate with an amine. The reaction typically requires a base such as potassium carbonate and is performed in an aprotic solvent like N,N-dimethylformamide (DMF) under an inert atmosphere. The yield is generally around 70-80%, with good selectivity towards the desired product.

Tert-butyl 4-amino-1H-indazole-1-carboxylate (CAS: 8016-13-5) is primarily used in the pharmaceutical industry for the synthesis of drugs. It is also utilized in the chemical industry for the development of new materials, and in the analytical sector for sensor applications due to its functional groups and structural features.

When handling Tert-butyl 4-amino-1H-indazole-1-carboxylate (CAS: 8016-13-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate absorbents, and the area should be washed down. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed information on safe handling and emergency procedures.