3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride(CAS: 69399-79-7)

3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride is a crystalline solid with a molecular weight of approximately 319.65 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and ethanol. This compound is chemically reactive, particularly towards nucleophiles and can undergo substitution reactions. It is stable under normal laboratory conditions but should be handled with care due to its reactivity.

3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride can be synthesized via the reaction of 2-chloro-6-fluorophenyl isothiocyanate with 5-methyl-1,2-oxazole-4-carbonyl chloride. This process often involves the use of a base like triethylamine to facilitate the reaction. The yield and selectivity can be improved by optimizing reaction conditions such as temperature and solvent choice.

3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride is used in the pharmaceutical industry for developing new drugs, particularly in the modification of drug molecules. It is also utilized in the synthesis of certain polymers and in the manufacture of sensors and semiconductors due to its chemical properties.

When handling 3-(2-Chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride, it is crucial to wear protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to avoid inhalation. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and guidance.