Methyl 3-chloro-5-nitrobenzoate(CAS: 36138-28-0)

Methyl 3-chloro-5-nitrobenzoate has a crystalline form and a molecular weight of approximately 240.03 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with bases to form the corresponding anion. It has a pKa of about 2.8 and a melting point of around 130°C.

Methyl 3-chloro-5-nitrobenzoate can be synthesized via nitration of methyl benzoate followed by chlorination. Commonly, the nitration is performed using nitric acid and sulfuric acid mixture, and chlorination is achieved using thionyl chloride. The overall process involves careful control of temperature and concentration to achieve high yield and selectivity.

Methyl 3-chloro-5-nitrobenzoate is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring specific functional groups. It is also utilized in the polymer industry for the preparation of special polymers and in the sensor industry for developing gas sensing materials. Additionally, it has applications in semiconductor technology as a precursor for certain compounds.

When handling Methyl 3-chloro-5-nitrobenzoate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risk. Store it in a cool, dry place away from direct sunlight and heat sources. In case of a spill, neutralize the compound with a base and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.