2,8-Diazaspiro[4.5]decan-3-one(CAS: 561314-57-6)

2,8-Diazaspiro[4.5]decan-3-one is a colorless to white crystalline solid with a molecular weight of approximately 186.23 g/mol. It has a melting point of 51-52°C and is slightly soluble in water. It exhibits good solubility in organic solvents like methanol, ethanol, and acetone. The compound is known for its reactivity, particularly in nucleophilic addition reactions, making it useful in organic synthesis.

2,8-Diazaspiro[4.5]decan-3-one can be synthesized via a Wittig reaction between 2,8-diazaspiro[4.5]decane and methyl chloroformate, using cesium carbonate as a base and a solvent, such as toluene. The reaction yields a high selectivity towards the target compound with good to excellent yield, depending on reaction conditions.

2,8-Diazaspiro[4.5]decan-3-one is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the development of functional materials and in the sensor industry for its sensing properties. Additionally, it has potential uses in semiconductor manufacturing for specific chemical processes.

When handling 2,8-Diazaspiro[4.5]decan-3-one, it is crucial to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood. In case of a spill, immediately clean up with caution and dispose of waste according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.