2-(Chloromethyl)tetrahydrofuran(CAS: 3003-84-7)

2-(Chloromethyl)tetrahydrofuran is a colorless liquid at room temperature. Its molecular weight is approximately 126.02 g/mol. It is slightly soluble in water but miscible with common organic solvents like ethanol and ether. This compound is known for its reactivity, particularly towards nucleophiles and elimination reactions.

2-(Chloromethyl)tetrahydrofuran is usually synthesized through the reaction of 1,4-dioxane with chloroform in the presence of a base. The reaction proceeds through an SN2 mechanism, yielding a high yield of the desired product. Sodium hydride is often used as a base in this synthesis.

2-(Chloromethyl)tetrahydrofuran is used in various industries, including pharmaceuticals for intermediate synthesis, polymers for functionalization, and sensors for detection purposes. It is also employed in semiconductor manufacturing for cleaning and etching processes.

When handling 2-(Chloromethyl)tetrahydrofuran, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood to minimize exposure to fumes. In case of spills, it is important to follow the emergency spill response procedure outlined in the safety data sheet (SDS).