2-Chloro-1,5-dinitro-3-(trifluoromethyl)benzene(CAS: 392-95-0)

2-Chloro-1,5-dinitro-3-(trifluoromethyl)benzene is a crystalline solid with a molecular weight of approximately 340.01 g/mol. It has low water solubility (less than 1 g/L) and a high melting point around 220°C. This compound is highly reactive due to the presence of nitro and trifluoromethyl groups, which can participate in various chemical reactions, including nitration and reduction.

2-Chloro-1,5-dinitro-3-(trifluoromethyl)benzene is usually synthesized by nitration of 2-chloro-1,3-dinitrobenzene followed by fluorination. The reaction involves the use of nitric acid and sulfuric acid as reagents for nitration, and triflic anhydride for fluorination. The process typically yields high selectivity and excellent purity.

2-Chloro-1,5-dinitro-3-(trifluoromethyl)benzene is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving nitro and halogen functionalities. It is also utilized in the polymer and semiconductor industries for specific applications requiring high reactivity and stability.

Handling 2-Chloro-1,5-dinitro-3-(trifluoromethyl)benzene requires strict safety measures. Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a respirator. Work in a fume hood due to its volatility and reactivity. Ensure proper storage in a cool, dry place away from incompatible substances. In case of a spill, follow the safety data sheet (SDS) guidelines for disposal and clean-up.