[4-(Bromomethyl)phenyl]boronic acid(CAS: 68162-47-0)

[4-(Bromomethyl)phenyl]boronic acid is a white crystalline solid with a molecular weight of approximately 263.05 g/mol. It has limited solubility in water and is soluble in organic solvents like ethanol and DMSO. Chemically, it is moderately reactive, particularly with nucleophiles and can participate in boronate ester formation. It is often used in organic synthesis and biochemistry.

[4-(Bromomethyl)phenyl]boronic acid is commonly synthesized via a one-pot reaction involving bromomethylbenzene and boronic acid in the presence of a base such as potassium carbonate. The reaction involves nucleophilic aromatic substitution followed by boronation, yielding the desired compound with good selectivity and moderate yield.

[4-(Bromomethyl)phenyl]boronic acid is primarily used in the pharmaceutical and chemical industries. It is utilized in the synthesis of various organic compounds, drug intermediates, and as a reagent in biochemistry and analytical chemistry for its reactivity in boronate ester formation and its role in asymmetric synthesis.

When handling [4-(Bromomethyl)phenyl]boronic acid, it is important to use personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be cleaned up carefully with appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and handling procedures.