3'-O-Methylguanosine(CAS: 10300-27-3)

3'-O-Methylguanosine is a nucleoside with a molecular weight of approximately 317.24 g/mol. It has a crystalline form and is poorly soluble in water. It is relatively stable under normal conditions but can be reactive towards strong acids and bases. This compound is used as a research tool and in pharmaceutical applications.

3'-O-Methylguanosine is typically synthesized by methylation of guanosine using dimethyl sulfate or similar methylating agents. The reaction is catalyzed by anhydrous conditions and is carried out with high selectivity, yielding a high purity product. The overall yield is around 80-90%.

3'-O-Methylguanosine is primarily used in the pharmaceutical industry for research into RNA and gene therapy. It is also used in the development of antisense drugs and as a starting material for the synthesis of other nucleosides. Some applications include the production of nucleic acid-based diagnostic tools and in biotechnology research.

When handling 3'-O-Methylguanosine, it is important to use appropriate personal protective equipment (PPE) such as gloves and goggles. It should be stored in a fume hood or well-ventilated area. In case of a spill, immediately clean up with appropriate absorbent material and dispose of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.