Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)(CAS: 40216-83-9)

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) is a chiral compound with the chemical formula C5H11NO3·HCl. It is derived from L-proline, featuring a methyl group at the 4-position and a hydroxyl group, making it a key intermediate in pharmaceutical and biochemical research. This compound is commonly used as a building block for drug synthesis and has applications in organic chemistry due to its structural versatility and reactivity.

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) is primarily used in pharmaceutical research for developing chelating agents and drug molecules. It serves as a precursor in the synthesis of amino acid derivatives and is applied in biochemical studies to investigate enzyme inhibition and protein interactions. Additionally, it is used in industrial processes for organic compound manufacturing and in food science as a flavor enhancer or stabilizer.

Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) is generally considered safe when handled properly. However, it may cause mild irritation to the skin or eyes and is corrosive to metals. Safety precautions include wearing gloves, goggles, and a lab coat, ensuring proper ventilation, and avoiding direct contact. It complies with standard chemical safety regulations for laboratory use, but adherence to safety guidelines is essential to minimize risks.

This compound should be stored in a tightly sealed container in a cool, dry place (ideally 25°C) with humidity below 60%. Protection from light is recommended to maintain stability. It is best kept in a moisture-proof environment to prevent degradation, and storage should avoid exposure to air or moisture to ensure shelf life and chemical integrity.