2-Methyl-2-propanyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate(CAS: 864770-82-1)

2-Methyl-2-propanyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate (CAS: 864770-82-1) is a white crystalline solid with a molecular weight of approximately 451.45 g/mol. It has limited water solubility and good solubility in organic solvents like methanol and dichloromethane. This compound is reactive towards nucleophiles and can undergo deprotection under basic conditions. It is stable under standard storage conditions but should be stored in a dry, cool place away from strong acids and bases.

2-Methyl-2-propanyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate (CAS: 864770-82-1) is typically synthesized via a multistep route involving the coupling of a boronic acid derivative with an indazole carboxylic acid under palladium catalysis. The reaction is conducted in the presence of a base such as potassium carbonate and a Pd(II) catalyst. The product can be isolated by filtration and purified using column chromatography.

2-Methyl-2-propanyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate (CAS: 864770-82-1) is primarily used in the pharmaceutical industry as a precursor for organic synthesis. It is also utilized in the development of materials for sensors and semiconductors due to its unique reactive properties and stability.

When handling 2-Methyl-2-propanyl 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate (CAS: 864770-82-1), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. The reaction should be carried out in a fume hood due to the potential for the release of volatile substances. Spills should be cleaned up using appropriate absorbents and disposed of in accordance with local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.