2,6-Di-O-methyl-β-cyclodextrin(CAS: 51166-71-3)

2,6-Di-O-methyl-β-cyclodextrin is a cyclic oligosaccharide derivative with a molecular weight of approximately 1,322 g/mol. It is a white, crystalline solid with good solubility in water. Chemically, it is known for its ability to form inclusion complexes with a wide range of guest molecules, enhancing their solubility and stability. Its reactivity is moderate, with limited chemical reactivity compared to other cyclodextrins.

2,6-Di-O-methyl-β-cyclodextrin is typically synthesized via the etherification of β-cyclodextrin with methyl iodide in the presence of an alkali catalyst, such as potassium hydroxide. The reaction is conducted in a solvent like dimethylformamide (DMF) under mild conditions. The selectivity and yield of the reaction are high, making this method a preferred choice for industrial production.

2,6-Di-O-methyl-β-cyclodextrin is widely used in the pharmaceutical industry for drug delivery systems, enhancing the solubility and stability of poorly soluble drugs. It is also utilized in the food industry for flavor encapsulation and anti-caking agents. Additionally, it finds applications in the polymer industry for modifying the properties of polymers and in the sensor and semiconductor industries for its unique inclusion properties.

When handling 2,6-Di-O-methyl-β-cyclodextrin, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be performed in a fume hood to minimize inhalation exposure. In the event of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and follow standard laboratory safety procedures.