3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate(CAS: 886-74-8)

3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate (CAS: 886-74-8) is a white to off-white crystalline solid. Its molecular weight is approximately 298.8 g/mol. It is slightly soluble in water and soluble in ethanol. It is known for its low reactivity under normal conditions, but it can undergo hydrolysis in basic conditions. It has a pKa of around 7.5, indicating weak acidity.

3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate (CAS: 886-74-8) is typically synthesized by the reaction of 4-chlorophenol with 2-hydroxypropyl carbamate. The process involves the condensation of 4-chlorophenol with 2-hydroxypropyl isocyanate in the presence of a suitable base such as potassium carbonate. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF) at room temperature. The yield is usually around 70-80%, and the product is isolated by filtration and recrystallization.

3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate (CAS: 886-74-8) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of drugs. It is also utilized in the polymer industry for the modification of polymers to enhance their stability and reactivity. Additionally, it has applications in the sensor industry for the development of gas sensors, and in the semiconductor industry for the fabrication of certain components due to its carbamate functional group.

When handling 3-(4-Chlorophenoxy)-2-hydroxypropyl carbamate (CAS: 886-74-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound is not highly reactive, but it should be kept away from strong acids and bases to prevent hydrolysis. It should be stored in a cool, dry place, away from heat sources. In case of a spill, it should be cleaned up using appropriate methods, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.