1-(2-Bromo-5-chlorophenyl)ethanone(CAS: 935-99-9)

1-(2-Bromo-5-chlorophenyl)ethanone (CAS: 935-99-9) is a white crystalline solid with a molecular weight of approximately 251.03 g/mol. It has a low water solubility and is more soluble in organic solvents like dichloromethane and ethanol. Chemically, it is relatively stable but can undergo nucleophilic substitution reactions, particularly with alkoxides and amines.

1-(2-Bromo-5-chlorophenyl)ethanone is typically synthesized by bromination of 1-phenylethanone followed by chlorination of the resulting 2-bromo-1-phenylethanone. Alternatively, it can be prepared by reacting 1-phenylethanone with bromine in the presence of a base, and then chlorinating the product. The reaction usually requires a mild base like potassium carbonate and is carried out in an inert solvent like dichloromethane.

1-(2-Bromo-5-chlorophenyl)ethanone (CAS: 935-99-9) is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry as a monomer or intermediate for developing advanced polymers with specific properties. Additionally, it finds applications in the sensor technology sector for the fabrication of gas sensors, and in the semiconductor industry for the production of electronic materials.

When handling 1-(2-Bromo-5-chlorophenyl)ethanone (CAS: 935-99-9), it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work should be carried out in a well-ventilated area or under a fume hood to minimize exposure to toxic fumes. Spills should be cleaned up carefully, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.