3-Fluoroisonicotinic acid(CAS: 393-53-3)

3-Fluoroisonicotinic acid (CAS: 393-53-3) is a crystalline solid with a molecular weight of approximately 143.08 g/mol. It has a solubility in water of 1.5 g/L at 20°C. This compound is moderately acidic and can react with bases. It is also known for its poor solubility in organic solvents such as ethanol and acetone.

3-Fluoroisonicotinic acid (CAS: 393-53-3) can be synthesized by fluorinating isonicotinic acid using a phase transfer catalyst such as tetrabutylammonium fluoride in an aprotic solvent. The reaction typically proceeds with a yield of 80-85%. Other methods involve direct fluorination of nicotinic acid derivatives.

3-Fluoroisonicotinic acid (CAS: 393-53-3) is used in pharmaceuticals for the synthesis of certain medicinal compounds. It may also be employed in the development of polymers and sensors due to its unique chemical properties. Additionally, this acid can be utilized in semiconductor applications for specific chemical treatments.

When handling 3-Fluoroisonicotinic acid (CAS: 393-53-3), proper personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. Operations should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up with appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.