1-Isoquinolinecarboxylic acid(CAS: 486-73-7)

1-Isoquinolinecarboxylic acid is a crystalline solid with a molecular weight of approximately 158.17 g/mol. It is slightly soluble in water and has a pKa of about 3.5. Chemically, it is a weak acid and can undergo reactions such as esterification and amide formation.

1-Isoquinolinecarboxylic acid is often synthesized via the condensation of isoquinoline with carbon dioxide. This process can be catalyzed by an appropriate acid or base. The yield can be improved by using a suitable catalyst, such as p-toluenesulfonic acid, and optimizing reaction conditions.

1-Isoquinolinecarboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs, and in the polymer industry as a cross-linking agent. It is also utilized in the production of sensors and as a precursor in semiconductor manufacturing.

When handling 1-Isoquinolinecarboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Always work in a well-ventilated area or fume hood to avoid inhalation of fumes. Spills should be cleaned up immediately using suitable absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions.