tert-Butyl ((2-aminopyridin-4-yl)methyl)carbamate(CAS: 474809-21-7)

tert-Butyl ((2-aminopyridin-4-yl)methyl)carbamate is a white to off-white solid with a molecular weight of approximately 261.29 g/mol. It has a solubility of about 0.3 g/100 mL in water and is slightly soluble in common organic solvents like methanol and ethanol. The compound is reactive towards nucleophiles and can undergo hydrolysis under basic conditions. It is stable under normal storage conditions but should be protected from moisture and heat.

tert-Butyl ((2-aminopyridin-4-yl)methyl)carbamate is commonly synthesized via the reaction of 2-aminopyridine-4-carboxylic acid with tert-butyl isocyanide in the presence of a coupling agent such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction proceeds with good yield and selectivity, typically yielding a pure product after column chromatography.

tert-Butyl ((2-aminopyridin-4-yl)methyl)carbamate is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for modifying the properties of polymers and in the sensor industry for developing chemical sensors. Additionally, it has potential applications in the semiconductor industry as a dopant or precursor material.

When handling tert-Butyl ((2-aminopyridin-4-yl)methyl)carbamate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and heat. Fume hoods should be used during handling to minimize inhalation risk. In case of spill, it should be contained and disposed of according to laboratory safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed safety information.