5-hydroxy-4-propyl-2,5-dihydrofuran-2-one(CAS: 78920-10-2)

5-hydroxy-4-propyl-2,5-dihydrofuran-2-one is a colorless or white crystalline solid with a molecular weight of approximately 132.15 g/mol. It has a moderate solubility in common organic solvents such as ethanol and methanol. The compound is known for its reactivity, particularly towards nucleophiles and electrophiles. It is stable under normal conditions but should be stored in a sealed container at room temperature to avoid degradation.

5-hydroxy-4-propyl-2,5-dihydrofuran-2-one can be synthesized via the condensation of propionaldehyde and 2-hydroxy-4-oxo-1,3-dioxol-5-one. The reaction typically uses a mild base such as potassium carbonate in an aqueous-organic solvent mixture. The yield is generally good, and the selectivity is high, making it a reliable method for producing this compound.

5-hydroxy-4-propyl-2,5-dihydrofuran-2-one is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for the production of certain polymers with specific properties. Additionally, it finds applications in the sensor technology for detecting specific chemicals and in semiconductor manufacturing for specific etching processes.

When handling 5-hydroxy-4-propyl-2,5-dihydrofuran-2-one, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of a spill, immediately clean it up using appropriate absorbents and dispose of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.