N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine(CAS: 153436-53-4)

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine is a crystalline solid with a molecular weight of approximately 354.13 g/mol. It has limited water solubility, with a solubility of around 0.1 g/L. This compound shows moderate reactivity with bases and shows minimal reactivity with acids. It is stable under normal storage conditions and has a melting point around 270-272°C.

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine is typically synthesized through a multi-step process involving the reaction of 3-chlorobenzaldehyde with 6,7-dimethoxyquinazoline-4-carbohydrazide. The synthesis involves condensation and reduction steps, with good selectivity and a yield of up to 85%. Catalytic amounts of catalytic palladium complexes are often used to enhance the reaction efficiency.

N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine is primarily used in the pharmaceutical industry for the development of new drugs. It also finds applications in the chemical and dye industries due to its unique structure and reactivity. Additionally, it is occasionally used in the synthesis of other organic compounds and as a precursor in materials science.

When handling N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine, it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It should be used in a well-ventilated fume hood to prevent inhalation. In case of a spill, contaminated clothes should be removed immediately and the area should be flushed with water. For more detailed information, refer to the Safety Data Sheet (SDS) for this compound.