Tirapazamine(CAS: 27314-97-2)

Tirapazamine (CAS: 27314-97-2) is a crystalline compound with a molecular weight of approximately 326.32 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is known to have low reactivity, making it stable under typical storage conditions. Its solubility in water is around 1 mg/mL at 25°C, and it is stable under basic and acidic conditions.

Tirapazamine (CAS: 27314-97-2) is synthesized via a multi-step process involving the installation of a nitro group followed by reduction, followed by the installation of an amino group. The synthesis typically uses sodium borohydride as a reducing agent and proceeds with good yield. The reaction conditions are optimized to ensure high purity and selectivity.

Tirapazamine (CAS: 27314-97-2) is primarily used in the pharmaceutical industry for its antineoplastic properties. It is also studied in the field of biomedical engineering for its potential applications in improving oxygen delivery in hypoxic tissues.

Tirapazamine (CAS: 27314-97-2) should be handled in a well-ventilated area, preferably in a fume hood. Proper personal protective equipment (PPE) including gloves and safety goggles should be worn. Spills should be cleaned up using appropriate absorbent materials, and the area should be flushed with water. The safety data sheet (SDS) should be consulted for detailed handling and disposal information.