ethyl 2-cyano-4,4-diethoxybutanoate(CAS: 52133-67-2)

Ethyl 2-cyano-4,4-diethoxybutanoate is a colorless to slightly yellow liquid at room temperature. Its molecular weight is approximately 258.25 g/mol. It has a pKa of around 14, indicating basicity. This compound is soluble in common organic solvents such as ethanol and acetone. Chemically, it is reactive towards nucleophiles and can undergo ester hydrolysis or cyanide displacement reactions.

Ethyl 2-cyano-4,4-diethoxybutanoate is commonly synthesized via the reaction of 2-cyano-4,4-diethoxybutanoyl chloride with ethanol. This reaction requires a suitable catalyst for better control over the diesterification step, often using a phase transfer catalyst. The yield is generally around 85-90%, with high selectivity towards the desired product.

Ethyl 2-cyano-4,4-diethoxybutanoate finds application in the pharmaceutical industry for the synthesis of certain intermediates. It is also used in the polymer industry as a monomer or additive, and in the sensor industry for the development of gas-sensitive materials. Its unique chemical properties make it suitable for use in semiconductors as well.

Proper Personal Protective Equipment (PPE) is essential when handling ethyl 2-cyano-4,4-diethoxybutanoate. This includes gloves, safety goggles, and a lab coat. It is recommended to use a fume hood to minimize exposure to vapors. Spills should be handled by neutralizing the cyanide group with a basic solution, followed by appropriate disposal. Always refer to the Safety Data Sheet (SDS) for more detailed safety information.