Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate(CAS: 178306-47-3)

Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate has a crystalline form with a molecular weight of approximately 334.37 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. Chemically, it is stable but reacts with strong acids and bases. It has a pKa of about 10.5.

Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate is synthesized via a multi-step process involving protection of the phenolic hydroxyl group, followed by methylation and deprotection. Commonly, the synthesis uses catalytic hydrogenation over palladium catalysts and selective alkylation reactions to achieve high yield and selectivity.

Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate is utilized in the pharmaceutical industry for its potential as a precursor in drug synthesis. It also finds applications in the polymer industry as a monomer and in the production of semiconductors due to its aromatic structure.

Handle Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate in a well-ventilated fume hood to avoid inhalation of fumes. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store it in a cool, dry place away from strong acids and bases. Refer to the safety data sheet (SDS) for more detailed handling and storage instructions.