5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine(CAS: 66335-37-3)

5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine is a white crystalline powder with a molecular weight of approximately 342.23 g/mol. It has poor solubility in water and ethanol but is soluble in dimethyl sulfoxide (DMSO). This compound is relatively stable under standard storage conditions but can be reactive in the presence of strong oxidizing agents. It is used in various chemical and pharmaceutical applications due to its unique structure.

5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine is synthesized through a multi-step process that includes the introduction of a fluorine atom and isopropylidene group to the cytidine structure. Common synthetic routes involve the use of protected cytidine derivatives, followed by fluorination and isopropylidene protection steps. The yield and selectivity of these reactions are crucial for the successful production of this compound.

5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine is primarily used in the pharmaceutical industry for the development of antiviral drugs and in the academic and research sectors for studying nucleoside chemistry. It is also of interest in polymer science for its potential applications in the synthesis of nucleic acid-based polymers.

When handling 5'-Deoxy-5-fluoro-2',3'-O-isopropylidenecytidine, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and laboratory coats. This compound should be stored in a cool, dry place away from direct sunlight. Spills should be handled using appropriate absorbent materials, and the area should be ventilated. Always refer to the material safety data sheet (MSDS) for specific handling and disposal instructions.