2-chloro-4,5-difluorobenzoic acid(CAS: 110877-64-0)

2-Chloro-4,5-difluorobenzoic acid is a crystalline solid with a molecular weight of approximately 211.03 g/mol. It has low water solubility and is slightly soluble in organic solvents. The compound is highly reactive towards nucleophilic substitution and can undergo electrophilic aromatic substitution reactions. Its physical properties include a melting point of 207-208°C and a density of 1.59 g/cm³.

2-Chloro-4,5-difluorobenzoic acid is typically synthesized through the chlorination of 4,5-difluorobenzoic acid using a Lewis acid catalyst such as aluminum chloride. The reaction involves the substitution of a chlorine atom at the 2-position of the benzene ring, providing a high yield and good selectivity.

2-Chloro-4,5-difluorobenzoic acid is used in various industries, including pharmaceuticals for the synthesis of active pharmaceutical ingredients, in polymer science for modifying the properties of polymers, and in the production of sensors and semiconductors due to its unique chemical structure.

When handling 2-chloro-4,5-difluorobenzoic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to prevent inhalation. Spills should be handled with caution using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed spill cleanup procedures.