5-Fluorouridine(CAS: 316-46-1)

5-Fluorouridine is a white crystalline powder with a molecular weight of 188.03 g/mol. It is soluble in ethanol, methanol, and water, but less so in organic solvents like chloroform. Chemically, it is a nucleoside derivative with good reactivity towards nucleophilic substitution reactions, making it a key intermediate in the synthesis of antiviral and anticancer drugs.

5-Fluorouridine is commonly synthesized through the reaction of 5-fluorouracil with uridine-5'-monophosphate (UMP) in the presence of a suitable catalyst such as sodium hydride. The process involves nucleophilic substitution and yields 5-fluorouridine with good selectivity and moderate yield, making it an efficient method for large-scale production.

5-Fluorouridine is primarily used in the pharmaceutical industry as an intermediate for the production of anti-cancer drugs, particularly fluorouracil (5-FU). It is also of interest in research for its potential applications in nucleic acid chemistry and biochemistry.

When handling 5-Fluorouridine, it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that work is conducted in a well-ventilated area or a fume hood to prevent inhalation or skin contact. In case of spills, evacuate the area and clean up using appropriate chemicals. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.