1-(4-Methyl-5-pyrimidinyl)ethanone(CAS: 87379-42-8)

1-(4-Methyl-5-pyrimidinyl)ethanone (CAS: 87379-42-8) is a white to off-white crystalline solid with a molecular weight of approximately 174.2 g/mol. It has a solubility of about 2.4 g/100 mL in water. The compound is moderately reactive and can undergo nucleophilic substitution reactions. It is insoluble in most organic solvents but soluble in polar aprotic solvents like dimethyl sulfoxide.

1-(4-Methyl-5-pyrimidinyl)ethanone can be synthesized through the condensation of 4-methylpyrimidine with acetic anhydride. The reaction typically proceeds under mild heating conditions with good selectivity and yield. The use of a suitable catalyst or solvent can enhance the reaction efficiency and product purity.

1-(4-Methyl-5-pyrimidinyl)ethanone (CAS: 87379-42-8) finds applications in various industries. It is commonly used in pharmaceuticals for the synthesis of certain drug intermediates. It also plays a role in the polymer industry as a precursor for functional polymers. Additionally, it is utilized in the development of sensors and semiconductors due to its unique chemical properties.

When handling 1-(4-Methyl-5-pyrimidinyl)ethanone (CAS: 87379-42-8), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be stored in a well-ventilated area and handled under a fume hood to prevent inhalation. In case of a spill, immediately clean it up using appropriate absorbent materials and ensure proper disposal. Always refer to the Safety Data Sheet (SDS) for detailed safety information.