2-(2,2,2-Trifluoroethoxy)phenol(CAS: 160968-99-0)

2-(2,2,2-Trifluoroethoxy)phenol (CAS: 160968-99-0) is a crystalline solid with a molecular weight of approximately 214.14 g/mol. It has a low solubility in water (0.033 g/L at 20°C) but is more soluble in organic solvents such as dichloromethane and acetonitrile. This compound exhibits moderate reactivity, particularly towards nucleophilic substituents, and is less reactive towards electrophiles. It is used in various applications due to its unique electronic properties.

2-(2,2,2-Trifluoroethoxy)phenol is typically synthesized via the reaction of 2,2,2-trifluoroethanol with phenol in the presence of a strong acid catalyst, such as hydrochloric acid. The process involves an etherification step where the hydroxyl group of phenol reacts with the trifluoroethoxy group of the alcohol, yielding the desired product with high selectivity and good yield.

2-(2,2,2-Trifluoroethoxy)phenol (CAS: 160968-99-0) is utilized in several industries, including pharmaceuticals, where it serves as a precursor for drug synthesis; polymers, where it can be used in the formulation of special plastics; and sensors, where its electronic properties are leveraged for detection applications. It also finds use in semiconductor manufacturing processes.

Proper handling of 2-(2,2,2-Trifluoroethoxy)phenol (CAS: 160968-99-0) requires the use of personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a well-ventilated area away from heat sources and flammable materials. In case of a spill, immediately clean up using appropriate absorbent materials and follow the manufacturer's safety data sheet (SDS) for disposal procedures. Always work in a fume hood to minimize inhalation risk.