(2S)-Tetrahydro-2-furancarboxylic acid(CAS: 87392-07-2)

(2S)-Tetrahydro-2-furancarboxylic acid is a white crystalline solid with a molecular weight of approximately 110.12 g/mol. It has a melting point of 128-129°C and a boiling point of 300°C. The compound is sparingly soluble in water but readily soluble in organic solvents like ethanol and acetone. It is moderately reactive, showing some tendency towards esterification and condensation reactions. It is a key intermediate in the synthesis of various pharmaceuticals and polymers.

(2S)-Tetrahydro-2-furancarboxylic acid is typically synthesized by the reduction of 2,5-furandicarboxylic acid with sodium borohydride or lithium aluminum hydride. The reaction is carried out in anhydrous ether or tetrahydrofuran, with careful control of the reduction conditions to achieve the desired stereochemistry. The yield is generally high, and the method is scalable for industrial applications.

(2S)-Tetrahydro-2-furancarboxylic acid is widely used in the pharmaceutical industry as a precursor for the synthesis of bioactive compounds. It also finds applications in the polymer industry for the preparation of functionalized polymers. Additionally, it is utilized in the development of new sensors and as a building block in the semiconductor industry for creating novel materials with specific electronic properties.

When handling (2S)-Tetrahydro-2-furancarboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and incompatible materials. Fume hoods should be used during operations to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.