5-Bromo-N-(pyridin-4-YL)pyrimidin-2-amine(CAS: 887433-72-9)

5-Bromo-N-(pyridin-4-YL)pyrimidin-2-amine (CAS: 887433-72-9) has a crystalline form with a molecular weight of approximately 269.03 g/mol. It is slightly soluble in water and ethanol. This compound is reactive towards nucleophiles and can undergo aromatic substitution reactions. It also exhibits good solubility in common organic solvents such as DMF and DMSO.

5-Bromo-N-(pyridin-4-YL)pyrimidin-2-amine is typically synthesized through a multi-step process involving bromination of a pyrimidine derivative followed by nucleophilic aromatic substitution with pyridine. The reaction is often catalyzed by Lewis acids and requires careful control of reaction conditions to achieve high selectivity and yield.

5-Bromo-N-(pyridin-4-YL)pyrimidin-2-amine (CAS: 887433-72-9) is used in the pharmaceutical industry for the synthesis of various drug candidates. It also finds use in the polymer industry as a precursor for functionalized materials. Additionally, it is utilized in sensor technologies and semiconductor manufacturing for specialized applications.

When handling 5-Bromo-N-(pyridin-4-YL)pyrimidin-2-amine (CAS: 887433-72-9), wear appropriate PPE such as gloves, goggles, and a lab coat. Work in a well-ventilated fume hood to avoid inhalation. Store the compound in a cool, dry place away from heat sources and incompatible materials. In case of spill, follow the safety data sheet (SDS) guidelines for disposal and clean-up.