2-Fluoro-5-Nitrobenzonitrile(CAS: 17417-09-3)

2-Fluoro-5-Nitrobenzonitrile is a crystalline solid with a molecular weight of approximately 214.05 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. This compound is relatively stable but can undergo nucleophilic substitution reactions. It is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and dyes.

2-Fluoro-5-Nitrobenzonitrile can be synthesized through the nitration of 2-fluorobenzonitrile followed by a selective reduction of the nitro group. This typically involves the use of concentrated nitric acid and sulfuric acid as the nitrating agent, with controlled conditions to achieve the desired product. The reaction is monitored to ensure selectivity and yield.

2-Fluoro-5-Nitrobenzonitrile is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those requiring fluorine-containing functional groups. It is also utilized in the production of dyes and pigments. Additionally, it finds applications in the preparation of materials for sensors and semiconductors due to its chemical properties.

Handling 2-Fluoro-5-Nitrobenzonitrile requires strict safety measures. It should be stored in a cool, dry place away from heat and sources of ignition. PPE such as gloves and goggles should be worn. Fume hoods should be used during handling to minimize exposure. In case of a spill, it should be handled according to the Safety Data Sheet (SDS) guidelines.