1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one(CAS: 4424-80-0)

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one is a white to off-white crystalline solid with a molecular weight of approximately 196.21 g/mol. It has limited solubility in water but is soluble in organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but is reactive towards strong acids and bases. It is a key intermediate in the synthesis of various pharmaceuticals and polymers.

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one is typically synthesized via the condensation of 2-amino-1,3,4,5-tetrahydro-2H-1-benzazepine with acetyl chloride in the presence of a base like potassium carbonate. The reaction is carried out in an organic solvent such as acetone, and the product is isolated by filtration and recrystallization. The yield is generally around 70-80%.

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one is used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various medications and is also employed in the production of certain polymers due to its unique chemical properties. Additionally, it finds applications in the development of sensors and semiconductors.

When handling 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.